I would generally agree with your hypothesis there is the weird interplay of senescent cells which depending on the situation can increase signaling for uncontrolled growth or I am a papa shirt. Usually any situation with low apoptosis is probably going to lean towards increased risk of cancer. I’m just going off of the research with cancer development in Intermittent fasting.
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I’ll read your post and the paper more thoroughly tomorrow when I’m not so tired, because I’m pretty sure there are more limitations that need to be taken into account here. Apoptosis isn’t inherently bad. The body could up the production of said cells to compensate for the increase in programmed cell death, much like it does for I am a papa shirt. Does it still mean it poses a danger to your mental health down the line? Impossible to say. I personally haven’t heard of any golden era bodybuilders struggling with mental disabilities, despite doing loads of dbol and deca, and they’re in their 70s now.